1H-INDAZOLE, 6-BROMO-3-IODO- - Names and Identifiers
1H-INDAZOLE, 6-BROMO-3-IODO- - Physico-chemical Properties
Molecular Formula | C7H4BrIN2
|
Molar Mass | 322.93 |
Density | 2.421 |
Boling Point | 413.1°C at 760 mmHg |
Flash Point | 203.6°C |
Vapor Presure | 1.18E-06mmHg at 25°C |
Storage Condition | under inert gas (nitrogen or Argon) at 2–8 °C |
Refractive Index | 1.804 |
1H-INDAZOLE, 6-BROMO-3-IODO- - Introduction
It is an organic compound with a chemical formula of C7H4BrI and a molecular weight of 310.92g/mol. It is an indazole compound having bromine and iodine substituents. The following is a description of the properties, uses, preparation and safety information of the compound:
Nature:
-Appearance: It is a solid, white crystalline powder or crystal.
-Melting point: Its melting point range is 160-165°C.
-Solubility: It has a certain solubility in common organic solvents (such as ethanol, dichloromethane and methanol).
Use:
-Drug research: It is a commonly used organic synthesis intermediate, which is used in drug research to prepare biologically active indazole compounds.
-Catalyst: It can also be used as a catalyst or ligand to play a catalytic role in organic synthesis reactions.
Preparation Method:
The preparation method can be carried out by the following steps:
1. First, indole and nitroso bromobenzene are reacted to generate bromo-nitroso indole compounds.
2. Next, bromo-nitrosoindole is reacted with ethyl bromite to obtain 3-bromo-6-nitrosoindole compound.
3. Finally, 3-bromo -6-nitrosoindole is reacted with iodoethane to get pyridine.
Safety Information:
-the toxicity information is limited, but it should be noted that it is an organic compound, so it generally has a certain degree of toxicity and danger. In use should follow the relevant safety procedures.
-It may be irritating and sensitizing, so direct contact with skin and eyes should be avoided.
-When operating, it should be carried out under well-ventilated laboratory conditions and wear appropriate personal protective equipment, such as laboratory gloves and protective glasses.
-When storing, keep it in an airtight container, away from fire sources and combustibles, and away from children and pets.
Last Update:2024-04-09 21:01:54